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KMID : 1161420100130010205
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Journal of Medicinal Food
2010 Volume.13 No. 1 p.205 ~ p.210
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Immunomodulatory Activity of Type-4 Resistant Starch in the Mesenteric Lymph Nodes of Rats
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Song Young-Ju
Bae Chun-Ho
Woo Dong-Ho
Kim Yun-Jung
Park Tae-Sun
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Abstract
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We evaluated the immunomodulatory activity of type-4 resistant starch (RS) in mesenteric lymph nodes (MLNs) using a rat model. Sixteen male Sprague-Dawley rats were fed either a cellulose diet or an RS diet (RSD) for 4 weeks. Serum immunoglobulin A levels, as well as the CD4+ T cell population and the ratio of CD4+/CD8+ T cells in the MLNs of rats, were significantly elevated by replacing cellulose with RS in the diet. The survival rate of concanavalin A (Con A)-stimulated MLN lymphocytes and interleukin-4 secretion from the Con A-stimulated MLN lymphocytes were significantly increased in rats fed RSD. These results indicate that type-4 RS might ameliorate allergic inflammation in the MLNs of rats through an increased CD4+ T cell population and enhanced differentiation of MLN lymphocytes into type-2 T cells.
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KEYWORD
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CD4+ T cells, CD4+/CD8+ ratio, immunoglobulin A, interleukin-4, intestinal immune response
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